Protein Modification Reagents
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Medchemexpress LLC Mal-PEG4-Val-Cit-PAB-PNP | 2112738-09-5 | 871.89 | C40H53N7O15 | 5 MG
Mal-PEG4-Val-Cit-PAB-PNP is a protease-cleavable, four-unit polyethylene glycol (PEG4) ADC linker containing a maleimide reactive group and a Val-Cit-PAB cleavable spacer. It is used in the synthesis of antibody-drug conjugates to provide protease-sensitive release of payloads.
- Protease-cleavable PEG4 linker useful for ADC synthesis.
- Maleimide reactive group enables thiol conjugation to antibodies.
- Val-Cit-PAB spacer provides protease-sensitive payload release.
- Soluble in DMSO (125 mg/mL) and formulatable for in vivo use (solubility ≥ 2.08 mg/mL with recommended solvent systems).
- Storage: protect from light; in solvent -80°C for 6 months, -20°C for 1 month.
- For research use only; not fully validated for medical applications.
![eMolecules Fmoc-Lys (biotin-PEG12)-OH | Broadpharm |1194.440 | C58H91N5O19S | 95.000 | OC(=O)C(CCCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)NC(=O)OCC1c2ccccc2-c2ccccc12 | 500mg | 272383804](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502203190.JPG-250.jpg)
eMolecules Fmoc-Lys (biotin-PEG12)-OH | Broadpharm |1194.440 | C58H91N5O19S | 95.000 | OC(=O)C(CCCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)NC(=O)OCC1c2ccccc2-c2ccccc12 | 500mg | 272383804
Fmoc-Lys (biotin-PEG12)-OH | Broadpharm |1194.440 | C58H91N5O19S | 95.000 | OC(=O)C(CCCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)NC(=O)OCC1c2ccccc2-c2ccccc12 | 500mg | 272383804
=O)[N+]([O-])=O | 1g | 112541436](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502202925.JPG-250.jpg)
eMolecules 1353011-89-8 | DNP-PEG2-acid | Broadpharm | MFCD20926369 | 343.292 | C13H17N3O8 | 98.000 | OC(=O)CCOCCOCCNc1ccc(cc1[N+]([O-])=O)[N+]([O-])=O | 1g | 112541436
DNP-PEG2-acid | Broadpharm | 1353011-89-8 | MFCD20926369 | 343.292 | C13H17N3O8 | 98.000 | OC(=O)CCOCCOCCNc1ccc(cc1[N+]([O-])=O)[N+]([O-])=O | 1g | 112541436
Medchemexpress LLC m-PEG5-azide | 1202681-04-6 | >98% | 250 MG
m-PEG5-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This click chemistry reagent incorporates an azide group, enabling its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules containing alkyne groups. It can also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds featuring DBCO or BCN groups. This compound is intended for research use only and has not been validated for medical applications. Recommended storage is at -20°C, sealed, and away from moisture.
- Used in the synthesis of PROTACs
- Features an azide group for click chemistry
- Participates in CuAAC reactions with alkyne-containing molecules
- Can undergo SPAAC reactions with DBCO or BCN groups
- Research use only
Broadpharm Methyltetrazine-amine HCl salt | 1345955-28-3 | MFCD30748954 | 25mg
Methyltetrazine-amine HCl salt | Putity: 95% | MW: 201.2 | 1345955-28-3 | MFCD30748954 | 25mg
![Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol)-folate] | 95.7% | 5000 (average) | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000281640.png-250.jpg)
Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol)-folate] | 95.7% | 5000 (average) | 25 MG
DSPE-PEG-Folate (MW 5000) is a pegylated lipid conjugate in which a DSPE lipid anchor is linked to a poly(ethylene glycol) chain terminated with folic acid. It is supplied as a solid and is formulated for use in liposomes, micelles, and other nanoparticle systems to enable folate receptor-mediated targeting and uptake.
- Provides folate receptor targeting for enhanced cellular uptake.
- Contains a DSPE lipid anchor for stable membrane insertion.
- Uses a PEG 5000 chain to improve circulation and reduce nonspecific clearance.
- High purity supports reproducible nanoparticle formulation.
- Supplied as a solid for convenient storage and handling.
Medchemexpress LLC Gly-Gly-Gly-PEG4-DBCO | 2353409-80-8 | 694.77 g/mol | C35H46N6O9 | 25 MG
Gly-Gly-Gly-PEG4-DBCO is a cleavable four-unit polyethylene glycol (PEG4) linker bearing a DBCO reactive group and a triglycine spacer. It is supplied as a powder for research use in bioconjugation and antibody-drug conjugate (ADC) synthesis, and enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.
- Cleavable 4-unit PEG linker suitable for bioconjugation.
- Contains a DBCO reactive group for copper-free click chemistry (SPAAC).
- Triglycine spacer (Gly-Gly-Gly) for peptide-compatible coupling.
- Available in multiple pack sizes, including 25 mg powder.
- Supplied as a powder with recommended storage at -20°C; in solvent store at -80°C for long term.
Medchemexpress LLC Ethanol, 2-(2-azidoethoxy)-, 1-(4-methylbenzenesulfonate) | 182347-24-6 | MFCD27946436 | 99.8% | 285.32 g/mol | C11H15N3O4S | 250 MG
N3-PEG2-Tos is a bifunctional PEG-based linker bearing an azide and a tosylate, designed for use as a small building block in click chemistry and bioconjugation. The product is supplied as a colorless to light yellow liquid with high analytical purity and defined storage recommendations for reliable handling in synthesis and research workflows.
- Azide functional group enables copper-catalyzed azide-alkyne cycloaddition.
- Tosylate leaving group allows nucleophilic substitution for linker installation.
- Small PEG2 spacer provides flexibility and solubility in conjugates.
- High purity (≈99.8%) supports analytical and synthetic applications.
- Stable under recommended storage conditions to preserve integrity.